A simulation study

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چکیده

In order to evaluate the efficacy of NetCutter in uniting genes regulated by common pathways in the same co-occurrence network community when samples of varying size are drawn, a simulation study was conducted. The simulated data set is used to reveal the impact of different user defined parameters onto the overall performance of NetCutter and to address problems connected with multiple testing. Furthermore, the relationship between Poisson-binomial P-values and Z-scores as well as the precision of the bibinomial approximation used by NetCutter to calculate P-values is discussed.

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تاریخ انتشار 2008